MANUFACTURER & EXPORTER OF BENIDIPINE API NIKSAN PHARMACEUTICAL



BENIDIPINE IS ONE OF THE MOST EFFECTIVE ANTIHYPERTENSIVE MOLECULES WHICH HAVE BEST EFFECT THAN EXCITING MOLECULES LIKE AMLODIPINE AND CILNIDIPINE. BENIDIPINE DOSE IS ONLY 2-8MG PER DAY. BENIDIPINE IS AVAILABLE IN MARKET IN FORM OF CHLORIDE SO, WE CAN SAY AS BENIDIPINE HYDROCHLORIDE.

NIKSAN PHARMACEUTICAL IS ONE OF THE LEADING MANUFACTURER AND EXPORTER OF BENIDIPINE API. BENIDIPINE IS L, T & N TYPE CALCIUM CHANNEL BLOCKER. IN 2013 CDSCO PUT AMLODIPINE IN DPCO SO, MANY PHARMACEUTICAL COMPANY IS SEARCHING ALTERNATIVE OF AMLODIPINE AND BENIDIPINE IS ONE OF THE BEST SOLUTIONS.

BENIDIPINE ADVANTAGES OVER AMLODIPINE AND CILNIDIPINE

1. ONE OF THE MAIN ADVANTAGES OF BENIDIPINE IS LESS DOSAGE COMPARE TO AMLODIPINE AND CILNIDIPINE
2. BENIDIPINE IS A NEW GENERATION TRIPLE L-, T-, AND N- TYPE CALCIUM CHANNEL BLOCKER USED AS ANTIHYPERTENSIVE AGENT.
3. BENIDIPINE EXERTED AN ANTIPROTEINURIC EFFECT TO A GREATER EXTENT THAN CILNIDIPINE IN PATIENTS WITH DIABETES.
4. BENIDIPINE EXERTED MORE PROTECTIVE EFFECTS AGAINST CARDIORENAL INJURY OF HYPERTENSIVE RATS THAN CILNIDIPINE, THROUGH MORE ATTENUATION OF OXIDATIVE STRESS THAN CILNIDIPINE, AND THE REDUCTION OF ALDOSTERONE. BENIDIPINE, VIA BLOCKADE OF T-TYPE CALCIUM CHANNELS, SEEMS TO ELICIT ADDITIVE BENEFITS FOR PREVENTION OF HYPERTENSIVE CARDIORENAL INJURY.

NOW, A DAYS BENIDIPINE IS AVAILBLE IN 4 MG AND 8 MG TABLETS IN MARKET. BENIDIPINE IS A RESEARCH MOLECULE OF JAPANESE. MAILNLY TWO RAW MATERIAL IS USED FOR THE MANUFACTURING OF BENIDIPINE WHICH IS CALL AS BENIDIPINE INTERMEDIATES AND INTERMEDIATES ARE AS 1-BENZYL-3-HYDROXYPIPERIDINE, CAS NO : 14813-01-5 AND 2,6-DIMETHYL-5-METHOXYCARBONYL-4-(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3-CARBOXYLIC ACID, CAS NO.: 74936-72-4 AND NIKSAN PHARMACEUTICAL IS ALSO MANUFACTURER OF BOTH BENIDIPINE INTERMEDIATES.

BENIDIPINE IS BINDING TO PLASMA PROTEIN IS VERY HIGHER THAN COMPARE WITH CILNIDIPINE AND AMLODIPINE, BENIDIPINE BIND WITH PLASMA PROTEIN ALMOST 98% AND ENTER TO SYSTEMIC CIRCULATION.

BENIDIPINE IS RAPIDLY ABSORBED BY BODY AFTER ADMINISTRATION OF BENIDIPINE TABLETS ORALLY AND IT’S REQUIRE ONLY 2 HOURS TO REACH ITS MAXIMUM CONCENTRATION. IF BENIDIPINE IS IN MICRONIZED FORM THAN THE TIME IS VERY LESS.

BENIDIPINE IS ONE OF THE MOLECULES WHICH METABOLIZED IN LIVER AND ITS MATABOLIZED BY CYP3A. METABOLIZED FORM IS N-DESBENZYLBENIDIPINE AND DEHYDROBENIDIPINE.

NIKSAN PHARMACEUTICAl is manufacturing and exporting BENIDIPINE from last many year in country like Brazil, Egypt, Singapore, Jordan, Lebanon, Israel, Vietnam, Bangladesh, Paraguay, Argentina, Dominican Republic, Sudan, Hong Kong, Seychelles, Algeria, Iran, Chile, South Korea, United Kingdom, Australia, Greece, Austria, Serbia, New Zealand, Sweden, Hungary, Mauritius, Vanuatu, Malta, Kazakistan, Slovenia, Bolivia, Japan, Uganda, Bulgaria, Lithuania, Poland, Sri Lanka, Romania, Uruguay, Russia, Thailand, Afghanistan, Latvia, Lithuania, United Arab Emirates, Seychelles, Peru, Switzerland, Tunisia, France, Australia, Hungary, Finland, Turkey, Pakistan, Rwanda, South Africa, Denmark, Malawi, Croatia, Slovenia, Ireland, Zambia, Cyprus, Nigeria, Uzbekistan, Cameroon, Netherlands, Azarbaijan, Venezuela, Morocco, Cote D Ivoire, St Lucia, South Korea, Congo, Philippines, Colombia, Burkina Faso, Sudan,Guinea, Djibouti, Netherlands, Nigeria and Germany. NIKSAN PHARMACEUTICAL highly appreciated manufacturer and exporter of BENIDIPINE. NIKSAN PHARMACEUTICAL provides all documents support for the BENIDIPINE with GMP and GLP support. NIKSAN PHARMACEUTICAL also support for Open Part of DMF of BENIDIPINE. NIKSAN PHARMACEUTICAL also manufacturing BENIDIPINE intermediates.

Products protected by valid patents are not offered for sale in countries where the sale of such products constitutes a patent infringement and its liability is at buyer’s risk.

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All Comments

  • CAN U HAVE IMPURITY OF BENIDIPINE

    ADITI RAJANI May 21, 2020 3:02 pm Reply
  • BENIDIPINE HCL JP WHAT PRICE

    ADITI RAJANI May 21, 2020 3:03 pm Reply
  • CAN U GIVE BASE OF BENIDIPINE

    ADITI RAJANI May 21, 2020 3:03 pm Reply
  • ARE YOU EXPORTING BENIDIPINE ?

    ADITI RAJANI May 21, 2020 3:03 pm Reply
  • Wow….Niksan Pharmaceuticals

    DILIP SAKHIYA May 21, 2020 3:03 pm Reply

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